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Perelson, Neumann, Markowitz, Leonard, Ho, 1996

ABSTRACT: Exposure with the id: perelson_neumann_markowitz_leonard_ho_1996

SUBMITTER: David Nickerson

PROVIDER: perelson_neumann_markowitz_leonard_ho_1996 | Physiome Model Repository |

REPOSITORIES: PMR

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HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.

Perelson A S AS Neumann A U AU Markowitz M M Leonard J M JM Ho D D DD

Science (New York, N.Y.) 19960301 5255

A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10(9 ...[more]

PMID: 8599114

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