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Snyed, Wetton, Charles, Sanderson, 1995

ABSTRACT: Intercellular calcium waves mediated by diffusion of inostol trisphosphate: a two dimensional model.

SUBMITTER: David Nickerson

PROVIDER: sneyd_wetton_charles_sanderson_1995 | Physiome Model Repository |

REPOSITORIES: PMR

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Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model.

Sneyd J J Wetton B T BT Charles A C AC Sanderson M J MJ

The American journal of physiology 19950601 6 Pt 1

In response to mechanical stimulation of a single cell, airway epithelial cells in culture exhibit a wave of increased intracellular free Ca2+ concentration that spreads from cell to cell over a limited distance through the culture. We present a detailed analysis of the intercellular wave in a two-dimensional sheet of cells. The model is based on the hypothesis that the wave is the result of diffusion of inositol trisphosphate (IP3) from the stimulated cell. The two-dimensional model agrees well ...[more]

PMID: 7611375

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