Dataset Information

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study: Plasma Proteomics analysis using SomaScan assay

ABSTRACT: This data was generated by the CHAIN cohort was primary aim was to identify the biological mechanisms underlying mortality among young children in sub-Saharan Africa and South Asia. Acutely ill children (n=3101) were admitted into the study at hospital admission. Children were then followed up for 6 months after hospital admission at days 45, 90 and 180. Blood was collected at hospital admission, discharge from hospital and follow-up time points. Plasma proteins were quantified from the blood collected at admission and discharge points.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Evans Mudibo

LAB HEAD: James M. Njunge

PROVIDER: PAD000021 | Pride | 2025-10-28

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MultiOmics_Protocol.pdf	Pdf
	SS-205089_SQS.pdf	Pdf
	SS-205089_v4.1_EDTAPlasma.hybNorm.medNormInt.plateScale.adat	Other
	SS-205089_v4.1_EDTAPlasma.hybNorm.medNormInt.plateScale.medNormRefSMP.adat	Other
	checksum.txt	Txt

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Publications

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia.

Njunge James M JM Mudibo Evans O EO Bogaert Jasper J Orindi Benedict B Sande Charles J CJ Bourdon Celine C Tigoi Caroline C Ngari Moses M MM Ngao Narshion N Omer Elisha E Gumbi Wilson W Musyimi Robert R Timbwa Molline M Mwaringa Shalton S Gwela Agnes A Thitiri Johnstone J Mupere Ezekiel E Lancioni Christina L CL Gonzales Gerard Bryan GB Singa Benson O BO Mbale Emmie E Voskuijl Wieger P WP Denno Donna M DM Diallo Abdoulaye Hama AH Bamouni Roseline Maϊmouna RM Chisti Mohammod Jobayer MJ Shahid Abu Sadat Mohammad Sayeem Bin ASMSB Ahmed Tahmeed T Saleem Ali Faisal AF Ali Syed Asad SA Uhlig Holm H HH Tickell Kirkby D KD Bandsma Robert H J RHJ Walson Judd L JL Berkley James A JA

Nature communications 20251128 1

In resource-limited settings, children often experience poor growth following illness, but the mechanisms are poorly understood. This cohort study in six countries in sub-Saharan Africa and south Asia investigates pathways linking inflammation and post-discharge weight gain among children hospitalised with acute illness. We determine associations between inflammation, enteropathy, growth mediators and other exposures at hospital discharge and weight gain during 90 days and explain how these expo ...[more]

PMID: 41315420

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