Proteomics

Dataset Information

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Inflammatory proteomics heterogeneity beyond glycemia status in severe obesity

ABSTRACT: In the present exploratory study, we aimed to characterize circulating inflam-matory protein profiles associated with glycemic status in individuals with severe obesity. Using proximity extension assay-based (PEA) proteomics, we first identified inflammatory proteins differentially expressed across normoglycemia, prediabetes, and T2DM and examined their distributions at the individual level. We then applied unsupervised topological data analysis to determine whether multidimensional in-flammatory protein patterns define distinct patient subgroups beyond conventional glycemic classification. By combining proteomic data, clinical variables, and network analysis, this study provides a hypothesis-generating view of inflammatory hetero-geneity in obesity-related dysglycemia.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Type 2 Diabetes Mellitus,Metabolic Dysfunction-associated Steatotic Liver Disease

SUBMITTER: Pablo Giraudi  

LAB HEAD: Pablo José Giraudi

PROVIDER: PAD000040 | Pride | 2026-06-08

REPOSITORIES: Pride

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2025.05.08_sample_manifest.xlsx Xlsx
checksum.txt Txt
dataset_all.npx.csv Csv
inflam_NASH_dt1.raw.csv Csv
inflam_PRA_dt2.raw.csv Csv
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Publications

Inflammatory Proteomic Heterogeneity Beyond Glycemia Status in Severe Obesity.

Milito Melissa M MM   Chiesa Mattia M   Mallia Alice A   Papaianni Giulia G GG   Regalado Julia T JT   Tiribelli Claudio C   Bonazza Deborah D   Rosso Natalia N   Palmisano Silvia S   Banfi Cristina C   Giraudi Pablo J PJ  

International journal of molecular sciences 20260506 9

Chronic low-grade inflammation is a key feature of obesity-associated dysglycemia, yet substantial heterogeneity exists in inflammatory responses among individuals with normoglycemia, prediabetes, and type 2 diabetes mellitus (T2DM). Whether circulating inflammatory protein profiles define distinct patient phenotypes beyond conventional glycemic classification remains incompletely understood. In this cross-sectional analysis of 142 individuals with severe obesity, plasma inflammatory proteins we  ...[more]

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