Inflammatory protein profiling shows limited ability to distinguish sepsis from sepsis mimics

ABSTRACT: This dataset contains normalized protein expression (NPX) measurements for 92 inflammatory proteins in 80 adult participants selected from four prospective cohorts in Japan for a retrospective case-control study. The primary comparison included 34 participants with sepsis and 46 with sepsis mimics: COVID-19 (n = 10), noninfectious acute respiratory distress syndrome (n = 7), atypical hemolytic uremic syndrome (n = 8), secondary hemophagocytic lymphohistiocytosis (n = 11), and TAFRO syndrome (n = 10). Serum was used for 69 participants and EDTA plasma for 11 participants with secondary hemophagocytic lymphohistiocytosis. Proteins were measured using the Olink Target 96 Inflammation panel on a single plate. The dataset includes study-specific sample identifiers, diagnostic groups, biospecimen types, sample-level quality-control status, assay identifiers, detection limits, and four technical control measurements. All 80 participants were retained in the primary analysis. Separate all-serum and QC-Pass sensitivity analyses included 69 and 68 participants, respectively. Original sample identifiers are not included. The study examined protein-level differences and multivariable discrimination between sepsis and sepsis mimics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Blood Serum

SUBMITTER: Daisuke Kasugai  

LAB HEAD: Daisuke Kasugai

PROVIDER: PAD000067 | Pride | 2026-10-22

REPOSITORIES: Pride