Dataset Information
Bantscheff-2007-1 - Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): ThermoFinnigan LTQ, ThermoFinnigan LCQ Deca XP, Waters Q-TOF Micro, Waters Q-TOF Ultima, ThermoFinnigan LTQ OrbiTrap, Waters Q-TOF II
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Placenta, K-562 Cell, Jurkat Cell, Hela Cell
SUBMITTER: 
Bernhard Kuester
LAB HEAD: Bernhard Kuester
PROVIDER: PRD000032 | Pride | 2007-08-26
REPOSITORIES: Pride
Dataset's files
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Publications
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors.
Nature biotechnology 20070826 9
We describe a chemical proteomics approach to profile the interaction of small molecules with hundreds of endogenously expressed protein kinases and purine-binding proteins. This subproteome is captured by immobilized nonselective kinase inhibitors (kinobeads), and the bound proteins are quantified in parallel by mass spectrometry using isobaric tags for relative and absolute quantification (iTRAQ). By measuring the competition with the affinity matrix, we assess the binding of drugs to their ta ...[more]
