Dataset Information
Natural killer cell secretory lysosome (granule) membrane proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model, QSTAR Pulsar
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Natural Killer Cell
SUBMITTER: 
Eric Hewitt
PROVIDER: PRD000049 | Pride | 2008-03-18
REPOSITORIES: Pride
Publications
Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.
Molecular & cellular proteomics : MCP 20070131 5
Natural killer (NK) cells and cytotoxic T lymphocytes eliminate virally infected and transformed cells. Target cell killing is mediated by the regulated exocytosis of secretory lysosomes, which deliver perforin and proapoptotic granzymes to the infected or transformed cell. Yet despite the central role that secretory lysosome exocytosis plays in the immune response to viruses and tumors, little is known about the molecular machinery that regulates the docking and fusion of this organelle with th ...[more]
