Proteomics

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Full aerobiosis - Expanding the known repertoire of virulence factors produced by Bacillus cereus through early secretome profiling in three redox conditions


ABSTRACT: shotgun comparison of aerobiosis to low and high ORP anaerobiosis

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Bacillus Cereus (strain Atcc 14579 / Dsm 31)

SUBMITTER: Jean ARMENGAUD  

PROVIDER: PRD000193 | Pride | 2011-05-05

REPOSITORIES: Pride

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Publications

Expanding the known repertoire of virulence factors produced by Bacillus cereus through early secretome profiling in three redox conditions.

Clair Gérémy G   Roussi Stamatiki S   Armengaud Jean J   Duport Catherine C  

Molecular & cellular proteomics : MCP 20100405 7


The pathogen Bacillus cereus causes diarrheal disease in humans. In the small intestine, B. cereus has to deal with anaerobiosis, low oxidoreduction potential, and carbohydrate limitation conditions. To gain insight into the virulence potential of low density B. cereus cells in such an environment, we cultured bacteria in low and high oxidoreduction potential anoxic conditions and in fully oxic conditions and compared their full secretomes. A unique pattern of proteins assigned to virulence fact  ...[more]

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