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Coxiella Burnetii - Identification of potentially involved proteins in levofloxacin resistance mechanisms in Coxiella burnetii

ABSTRACT: Coxiella Burnetii Nine Mile vs Nine Mile resistant to levofloxacine

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Coxiella Burnetii

SUBMITTER: Pieter-Jan De Bock

PROVIDER: PRD000262 | Pride | 2012-07-20

REPOSITORIES: Pride

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Identification of potentially involved proteins in levofloxacin resistance mechanisms in Coxiella burnetii.

Vranakis Iosif I De Bock Pieter-Jan PJ Papadioti Anastasia A Tselentis Yannis Y Gevaert Kris K Tsiotis Georgios G Psaroulaki Anna A

Journal of proteome research 20101207 2

The etiological agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that multiplies within a phagosome-like parasitophorous vacuole. Fluoroquinolones have been used as an alternative therapy for Q fever. Resistance to fluoroquinolones can arise via several mechanisms utilized by pathogens to avoid killing. Until today, genome-based studies have shown that the main mechanism of C. burnetii to resist inhibition by fluoroquinolones is based on mutations in quinolone-resistan ...[more]

PMID: 21070068

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