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Differential proteomic analysis of E2F2-/- T lymphocytes

ABSTRACT: Protein relative quantification based on 2-DE. T lymphocytes were activated with anti CD3 antibody

INSTRUMENT(S): instrument model

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell, Lymph Node

SUBMITTER: Mikel Azkargorta

PROVIDER: PRD000270 | Pride | 2010-07-20

REPOSITORIES: Pride

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Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes.

Azkargorta Mikel M Fullaondo Asier A Laresgoiti Usua U Aloria Kerman K Infante Arantza A Arizmendi Jesus M JM Zubiaga Ana M AM

Molecular & cellular proteomics : MCP 20100623 10

E2F transcription factors (E2F1-8) are best known for their role in cell proliferation, although it is clear that they regulate many other biological processes through the transcriptional modulation of distinct target genes. However, the specific set of genes regulated by each E2F remains to be characterized. To gain insight into the molecular pathways regulated by E2F2, we have analyzed the proteome of antigen receptor-activated T cells lacking E2F2. We report that loss of E2F2 results in a der ...[more]

PMID: 20573986

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