Dataset Information
Combine Approach HNE - Combined proteomic approaches for the identification of specific amino acid residues modified by 4-hydroxy-2-nonenal under physiological conditions
Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model, LTQ
SUBMITTER: 
MªLuisa hernáez
PROVIDER: PRD000286 | Pride | 2010-10-21
REPOSITORIES: Pride
Publications
Combined proteomic approaches for the identification of specific amino acid residues modified by 4-hydroxy-2-nonenal under physiological conditions.
Journal of proteome research 20101008 11
Proteins modified by 4-hydroxy-2-nonenal (HNE) are cellular markers of oxidative stress in health and disease. HNE is generated by free radical chain reactions during oxidative stress as a major end-product of the oxidative fatty acid metabolism. Identification and quantitative analysis of HNE-modified proteins are readily performed by using specific antibodies raised against them. Further on, the identification of the amino acid residues involved in the HNE-modification is an additional step in ...[more]
