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SQSTM1-interacting proteins in human osteoclasts

ABSTRACT: SQSTM1-interacting proteins in human osteoclasts

INSTRUMENT(S): Bruker Daltonics HCT Series, instrument model

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Osteoclast

SUBMITTER: Lynne Hocking

PROVIDER: PRD000309 | Pride | 2012-03-04

REPOSITORIES: Pride

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Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts.

Hocking Lynne J LJ Mellis David J DJ McCabe Paul S PS Helfrich Miep H MH Rogers Michael J MJ

Biochemical and biophysical research communications 20101029 3

Paget's disease of bone (PDB) is a late-onset disorder characterised by focal areas of increased bone resorption, with osteoclasts that are increased in size, multinuclearity, number and activity. PDB-causing missense and nonsense variants in the gene encoding Sequestosome-1/p62 (SQSTM1) have been identified, all of which cluster in and around the ubiquitin-associated (UBA) domain of the protein. SQSTM1 is ubiquitously expressed and there is, as yet, no clear reason why these mutations only appe ...[more]

PMID: 20971078

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