Dataset Information
Chemoproteomics profiling reveals that HDAC inhibitors bind to large protein complexes and display compound class-dependent selectivity
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJDB2856
INSTRUMENT(S): LTQ-Orbitrap
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Spleen, Heart, Thp-1 Cell, Brain, Burkitt Lymphoma Cell, Jurkat E-6.1 Cell, Liver, Lung, Hl-60 Cell, K-562 Cell, Kidney, Hela Cell
SUBMITTER: 
Attila Csordas
LAB HEAD: Attila Csordas
PROVIDER: PRD000345 | Pride | 2011-01-23
REPOSITORIES: Pride
Dataset's files
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Publications
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.
Nature biotechnology 20110123 3
The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and anti-inflammatory properties remains challenging in large part owing to the difficulty of probing the interaction of small molecules with megadalton protein complexes. A combination of affinity capture and quantitative mass spectrometry revealed the selectivity with which 16 HDAC inhibitors target multiple HDAC complexes scaffolded by ELM-SANT domain subunits, including a novel mitotic deacetylase complex (Mi ...[more]
