Proteomics

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Planarian Neoblast Proteomics - A proteomics approach to decipher the molecular nature of planarian stem cells


ABSTRACT: We have developed an accurate and reliable mass-spectra-based proteomics approach to complement previous genomic studies and to further achieve a more accurate understanding and description of the molecular and cellular processes related to the neoblasts.

INSTRUMENT(S): instrument model, 4700 Proteomics Analyzer

ORGANISM(S): Schmidtea Mediterranea (freshwater Planarian Flatworm)

SUBMITTER: Josep F Abril  

PROVIDER: PRD000350 | Pride | 2012-03-05

REPOSITORIES: Pride

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Publications

A proteomics approach to decipher the molecular nature of planarian stem cells.

Fernández-Taboada Enrique E   Rodríguez-Esteban Gustavo G   Saló Emili E   Abril Josep F JF  

BMC genomics 20110228


<h4>Background</h4>In recent years, planaria have emerged as an important model system for research into stem cells and regeneration. Attention is focused on their unique stem cells, the neoblasts, which can differentiate into any cell type present in the adult organism. Sequencing of the Schmidtea mediterranea genome and some expressed sequence tag projects have generated extensive data on the genetic profile of these cells. However, little information is available on their protein dynamics.<h4  ...[more]

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