Dataset Information
Protein corona liposomes - DNA affects the composition of lipoplex protein corona: a proteomics approach
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
SUBMITTER: 
Chiara Cavaliere
PROVIDER: PRD000364 | Pride | 2011-08-15
REPOSITORIES: Pride
Publications
DNA affects the composition of lipoplex protein corona: a proteomics approach.
Proteomics 20110713 16
The distribution of drug delivery systems into the body is affected by plasma proteins adsorbed onto their surface. Furthermore, an exact understanding of the structure and morphology of drug carriers is fundamental to understand their role as gene delivery systems. In this work, the adsorption of human plasma proteins bound to cationic liposomes and to their relative DNA lipoplexes was compared. A shotgun proteomics approach based on HPLC coupled to high resolution MS was used for an efficient ...[more]
