Plasmodium falciparum palmitome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, instrument model
ORGANISM(S): Plasmodium Falciparum
TISSUE(S): Schizont
DISEASE(S): Plasmodium Falciparum Malaria
SUBMITTER: 
Mark Collins
PROVIDER: PRD000459 | Pride | 2012-09-24
REPOSITORIES: Pride
Publications
Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.
Jones Matthew L ML Collins Mark O MO Goulding David D Choudhary Jyoti S JS Rayner Julian C JC
Cell host & microbe 20120801 2
Asexual stage Plasmodium falciparum replicates and undergoes a tightly regulated developmental process in human erythrocytes. One mechanism involved in the regulation of this process is posttranslational modification (PTM) of parasite proteins. Palmitoylation is a PTM in which cysteine residues undergo a reversible lipid modification, which can regulate target proteins in diverse ways. Using complementary palmitoyl protein purification approaches and quantitative mass spectrometry, we examined p ...[more]
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