Name: Differential proteomics - Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats
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Differential proteomics - Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats

ABSTRACT: Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats

INSTRUMENT(S): instrument model

ORGANISM(S): Rattus Norvegicus (rat)

SUBMITTER: Bent Honoré

PROVIDER: PRD000524 | Pride | 2011-09-28

REPOSITORIES: Pride

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Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.

Østergaard Louise L Honoré Bent B Thorsen Lise B LB Baandrup Jonas J Eskildsen-Helmond Yvonne Y Laursen Britt E BE Vorum Henrik H Mulvany Michael J MJ Simonsen Ulf U

Proteomics 20111028 23

The present study was designed to analyze protein expression in lungs from pulmonary hypertensive rats in order to identify novel signaling pathways. This was achieved by proteomic studies in which proteins from lung homogenates from hypoxic were compared to normoxic rats. The expression of these proteins was then investigated in lungs from hypoxic rats treated with either an activator of soluble guanylyl cyclase, BAY 412272, or an inhibitor of phosphodiesterase type 5, sildenafil. The proteomic ...[more]

PMID: 21905223

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