Proteomics

Dataset Information

239

Brucella - Investigation of rifampicin resistance mechanisms in Brucella abortus using MS-driven comparative proteomics


ABSTRACT: Brucella comparison

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Brucella  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Pieter-Jan De Bock  

PROVIDER: PRD000590 | Pride | 2012-03-30

REPOSITORIES: Pride

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Publications

Investigation of rifampicin resistance mechanisms in Brucella abortus using MS-driven comparative proteomics.

Sandalakis Vassilios V   Psaroulaki Anna A   De Bock Pieter-Jan PJ   Christidou Athanasia A   Gevaert Kris K   Tsiotis Georgios G   Tselentis Yiannis Y  

Journal of proteome research 20120321 4


Mutations in the rpoB gene have already been shown to contribute to rifampicin resistance in many bacterial strains including Brucella species. Resistance against this antibiotic easily occurs and resistant strains have already been detected in human samples. We here present the first research project that combines proteomic, genomic, and microbiological analysis to investigate rifampicin resistance in an in vitro developed rifampicin resistant strain of Brucella abortus 2308. In silico analysis  ...[more]

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