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Proteomic profiling of acute coronary thrombosis reveals a local decrease of PEDF in acute myocardial infarction

ABSTRACT: Human blood plasma was depleted using an Agilent Multiple Affinity Removal Hu-6 column

INSTRUMENT(S): Agilent XCT Ultra

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Platelet, Blood Plasma, Leukocyte, Blood

SUBMITTER: Christopher Gerner

LAB HEAD: Christopher Gerner

PROVIDER: PRD000631 | Pride | 2012-07-20

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_21300.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_21300.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_21300.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_21301.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_21301.pride.mztab.gz	Mztab

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Publications

Proteomic profiling of acute coronary thrombosis reveals a local decrease in pigment epithelium-derived factor in acute myocardial infarction.

Distelmaier Klaus K Adlbrecht Christopher C Jakowitsch Johannes J Wagner Oswald O Gerner Christopher C Lang Irene M IM Kubicek Markus M

Clinical science (London, England : 1979) 20120701 2

Thrombotic occlusion of an epicardial coronary artery on the grounds of atherosclerotic plaque is considered the ultimate step in AMI (acute myocardial infarction). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial infarction). Label-free quantification ...[more]

PMID: 22315956

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Project description:Peripheral blood mononuclear cells were collected from the patients. RNA-seq and analysis was performed on the collected samples. Total RNA was extracted from the tissue using TRIzol® Reagent according the manufacturer’s instructions(Invitrogen) and genomic DNA was removed using DNase I (TaKara). Then RNA quality was determined using 2100 Bioanalyser (Agilent) and quantified using the ND-2000 (NanoDrop Technologies). High-quality RNA sample (OD260/280=1.8~2.2, OD260/230≥2.0, RIN≥6.5, 28S:18S≥1.0, >10μg) is used to construct sequencing library

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Project description:Background Though rare, myocardial infarction secondary to coronary artery dissection is a life-threatening event. In reproductive age women, it commonly occurs during pregnancy or the postpartum period. Case We present a case of pregnancy-related acute myocardial infarction due to spontaneous coronary artery dissection in a 37-year-old woman who presented to the emergency room with shortness of breath and sudden onset of retrosternal chest pain 8 days after delivery of premature twins. Coronary artery catheterization showed 75 to 90% stenosis in the left main coronary artery (LMCA), extending into the proximal and mid left anterior descending (LAD) branch. The LMCA appearance in the heart catheterization was consistent with vasospasm, but it was not responsive to medical management. Subsequently, she underwent a second coronary artery catheterization and was found to have dissection requiring emergent coronary artery bypass graft × 3 in the LMCA, circumflex, and LAD that was followed by an uneventful recovery. Conclusion Early diagnosis and management of myocardial infarction due to coronary artery dissection in the peripartum period is crucial. This condition should be suspected in young reproductive age women, even in the setting of minimal risk factors. Angiography is required for diagnosis. Management should be individualized as it may include both invasive and noninvasive measures.

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Characterization of culprit-coronary artery miRNA expression in acute myocardial infarction male patients

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