Proteomics

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Proteomic profiling of acute coronary thrombosis reveals a local decrease of PEDF in acute myocardial infarction

ABSTRACT: Human blood plasma was depleted using an Agilent Multiple Affinity Removal Hu-6 column

INSTRUMENT(S): instrument model, Agilent instrument model

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Platelet, Blood Plasma, Leukocyte, Blood

SUBMITTER: Christopher Gerner  

PROVIDER: PRD000631 | Pride | 2012-07-20

REPOSITORIES: Pride

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Publications

Proteomic profiling of acute coronary thrombosis reveals a local decrease in pigment epithelium-derived factor in acute myocardial infarction.

Distelmaier Klaus K   Adlbrecht Christopher C   Jakowitsch Johannes J   Wagner Oswald O   Gerner Christopher C   Lang Irene M IM   Kubicek Markus M  

Clinical science (London, England : 1979) 20120701 2

Thrombotic occlusion of an epicardial coronary artery on the grounds of atherosclerotic plaque is considered the ultimate step in AMI (acute myocardial infarction). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial infarction). Label-free quantification  ...[more]

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