Proteomics

Dataset Information

0

BradelTretheway_2011_Comprehensive_proteomic_analysis_of_Influenza_Virus_Polymerase


ABSTRACT: Not available

INSTRUMENT(S): Thermo LTQ-Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Michael Katze  

LAB HEAD: Michael Katze

PROVIDER: PRD000671 | Pride | 2012-04-02

REPOSITORIES: Pride

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Publications

Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors.

Bradel-Tretheway Birgit G BG   Mattiacio Jonelle L JL   Krasnoselsky Alexei A   Stevenson Catherine C   Purdy David D   Dewhurst Stephen S   Katze Michael G MG  

Journal of virology 20110629 17


The trimeric RNA polymerase complex (3P, for PA-PB1-PB2) of influenza A virus (IAV) is an important viral determinant of pathogenicity and host range restriction. Specific interactions of the polymerase complex with host proteins may be determining factors in both of these characteristics and play important roles in the viral life cycle. To investigate this question, we performed a comprehensive proteomic analysis of human host proteins associated with the polymerase of the well-characterized H5  ...[more]

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