Functional interplay between the DNA-damage-response and Arf anti-tumor barriers
Ontology highlight
ABSTRACT:
INSTRUMENT(S): q-star
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Theodoros Roumeliotis
LAB HEAD: Theodoros Roumeliotis
PROVIDER: PRD000689 | Pride | 2013-06-19
REPOSITORIES: Pride
Dataset's files
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Publications
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Velimezi Georgia G Liontos Michalis M Vougas Konstantinos K Roumeliotis Theodoros T Bartkova Jirina J Sideridou Maria M Dereli-Oz Ayguel A Kocylowski Maciej M Pateras Ioannis S IS Evangelou Kostas K Kotsinas Athanassios A Orsolic Ines I Bursac Sladana S Cokaric-Brdovcak Maja M Zoumpourlis Vassilis V Kletsas Dimitris D Papafotiou George G Klinakis Apostolos A Volarevic Sinisa S Gu Wei W Bartek Jiri J Halazonetis Thanos D TD Gorgoulis Vassilis G VG
Nature cell biology 20130714 8
The DNA damage response (DDR) pathway and ARF function as barriers to cancer development. Although commonly regarded as operating independently of each other, some studies proposed that ARF is positively regulated by the DDR. Contrary to either scenario, we found that in human oncogene-transformed and cancer cells, ATM suppressed ARF protein levels and activity in a transcription-independent manner. Mechanistically, ATM activated protein phosphatase 1, which antagonized Nek2-dependent phosphoryl ...[more]
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