Proteomics

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A Combined Proteomic and Genetic Analysis of the Highly Variable Platelet Proteome: From Plasmatic Proteins and SNPs

ABSTRACT: Platelets were isolated from full blood by mild centrifugation (50g) and plasma proteins were removed by washing with tyrode-buffer

INSTRUMENT(S): instrument model, Agilent instrument model

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Platelet, Blood

SUBMITTER: Christopher Gerner  

PROVIDER: PRD000738 | Pride | 2012-08-15

REPOSITORIES: Pride

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A combined proteomic and genetic analysis of the highly variable platelet proteome: from plasmatic proteins and SNPs.

Veitinger Michael M   Umlauf Ellen E   Baumgartner Roland R   Badrnya Sigrun S   Porter Jonny J   Lamont John J   Gerner Christopher C   Gruber Christian W CW   Oehler Rudolf R   Zellner Maria M  

Journal of proteomics 20120804 18

High biological variation in protein expression represents a major challenge in clinical proteomics. In a study based on 2D-DIGE, we found that the standardised abundance of only a few proteins varied by more than 50%. While some of the highest variable proteins in platelets of 52 healthy elderly were of plasmatic origin, such as albumin or haptoglobin, absence of several other high-abundant plasma proteins strongly suggests that plasma-derived proteins represent an integral part of the platelet  ...[more]