Dataset Information
Identification of Ricin and Concanavalin A-binding Trypanosoma brucei Glycoproteins
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, instrument model
ORGANISM(S): Trypanosoma Brucei Brucei
SUBMITTER: 
Joao Rodrigues
PROVIDER: PRD000808 | Pride | 2009-06-01
REPOSITORIES: Pride
Publications
Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases.
The EMBO journal 20090723 17
Asparagine-linked glycosylation is catalysed by oligosaccharyltransferase (OTase). In Trypanosoma brucei OTase activity is catalysed by single-subunit enzymes encoded by three paralogous genes of which TbSTT3B and TbSTT3C can complement a yeast Deltastt3 mutant. The two enzymes have overlapping but distinct peptide acceptor specificities, with TbSTT3C displaying an enhanced ability to glycosylate sites flanked by acidic residues. TbSTT3A and TbSTT3B, but not TbSTT3C, are transcribed in the blood ...[more]
