Name: Proteomic analysis of mitochondrial damage in PBMC of HIV-infected patients
Keywords: Not available

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Proteomic analysis of mitochondrial damage in PBMC of HIV-infected patients

ABSTRACT: Not available

INSTRUMENT(S): 4800 Plus MALDI TOF/TOF, instrument model

SUBMITTER: Gian Maria Fimia

PROVIDER: PRD000820 | Pride | 2010-07-13

REPOSITORIES: Pride

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Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients.

Ciccosanti Fabiola F Corazzari Marco M Soldani Fabio F Matarrese Paola P Pagliarini Vittoria V Iadevaia Valentina V Tinari Antonella A Zaccarelli Mauro M Perfettini Jean-Luc JL Malorni Walter W Kroemer Guido G Antinori Andrea A Fimia Gian Maria GM Piacentini Mauro M

Antiviral therapy 20100101 3

<h4>Background</h4>Highly active antiretroviral therapy (HAART) has largely reduced the occurrence of AIDS-related diseases and death in HIV-infected patients. However, HAART produces serious side effects mainly attributed to mitochondrial toxicity.<h4>Methods</h4>To elucidate the molecular basis of HAART-related dysfunctions, we analysed the mitochondrial proteome of peripheral blood mononuclear cells from HIV-infected patients using two-dimensional gel electrophoresis and MALDI-TOF/TOF mass sp ...[more]

PMID: 20516557

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