Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HIgh fat refined sugar diet and hippocampus

ABSTRACT: Rats were fed either a control diet or high fat and refined sugar (HFS) diet and hippocampus was resected for proteomic analysis

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

SUBMITTER: Heather Francis

LAB HEAD: Heather Francis

PROVIDER: PXD000028 | Pride | 2012-09-14

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	030910dorsalhippcontrolsample1.zip	Other
	030910dorsalhippcontrolsample2.zip	Other
	070910dorsalhippHFSsample1.zip	Other
	120111dorsalhippcontrolsample3.zip	Other
	191110dorsalhippHFSsample2.zip	Other

Items per page:

1 - 5 of 12

Similar Datasets

RNA-next generation sequencing of intestine tissue from mice fed high fat diet or/and sugar drink

Project description:Purpose: NGS was used to determine if a distinct transcriptomic profile is observed among the experimental mice fed four different dietary components. Methods: We carried out RNA-Seq analysis of ileum tissue from 6 weeks male mice ad libitum fed for 10 weeks a high liquid sugar (23% (w/v)) or/and high fat (60% Kcal from fat) diet. The combined effect of sugar drink and high fat diet (HF-Sugar) was compared with sugar drink only (NF-Sugar), or high fat diet only (HF), or control diet that was plain water and normal fat diet (NF). Results: RNA-Seq revealed sample-specific clusters that included genes responding to each experimental diet. We found only addition of sugar drink to high fat group (HF-Sugar) not NF-Sugar and HF, there was a significant enrichment in biological functions relating to Inflammatory/Immune Responses, especially including dendritic cell (DC) and T cell related signaling pathway. Conclusions: Taken together, our data demonstrate that sugar drink synergistically promotes and exacerbates inflammatory responses driven by the high fat diet.

2021-11-25 | GSE140972 | GEO

Transcriptome of GCKR-P446L-EMI-B6N on a high-fat high-sugar diet

Project description:Transcriptome of GCKR-P446L-EMI-B6N on a high-fat high-sugar diet

2023-04-19 | GSE228698 | GEO

Effects of high sugar diet on gene expression in the Drosophila labellum

Project description:Driven by findings that exposure to a high sugar diet reduced taste sensation in Drosophila, we performed RNA-seq on isolated proboscis tissue from animals that had either received a sugar diet or a control diet. Subsequently, we also profiled expression of animals expressing an RNAi construct to knock down OGT transcript levels in Gr5a+ neurons.

2019-06-20 | GSE113159 | GEO

A low sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms

Project description:We report sex differences in mRNA levels between male and female Drosophila larvae reared on a diet containing sugar (1S) vs a -low-sugar diet (0S)

2022-03-14 | GSE198435 | GEO

Hepatocyte RNA-seq analysis in liver-specific XBP1 knockout mice fed a high fat sugar diet

Project description:X-box binding protein 1 (XBP1) is a key component of the unfolded protein response (UPR) and plays important roles in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD). Mice with liver-specific XBP1 deletion developed great liver injury and fibrosis in a dietary model of NAFLD. This project is to investigate hepatocyte-specific transcriptome profiling in XBP1-deficient mice fed a high fat sugar diet.

2022-01-03 | GSE190947 | GEO

Differential transcriptional networks regulated by high sugar consumption in normal and high-fat-fed mice

Project description:High sugar consumption, as well as high-fat diet, is a known cause of obesity and metabolic syndrome. However, the synergistic effect of high-sugar and high-fat consumption rarely has been evaluated, especially in terms of transcriptional regulation. Therefore, we focused on the effect of high sugar consumption on hepatic transcriptional networks in normal and high fat-fed mice. C57BL/6J mice were divided into four groups and were provided either 23%(w/v) sugar solution or plain water with either high-fat or normal-fat diet for 10 weeks. As a result, high sugar consumption significantly altered lipid metabolism-related genes in normal fat-fed mice; however, in high fat-fed mice, high sugar consumption altered inflammation-responsive genes rather than lipid metabolism. After all, these modulations eventually increased lipid accumulation in the liver and caused systemic metabolic disturbances. These observations for the first time suggested that high sugar consumption along with high-fat diet could lead to the development of severe metabolic syndrome via altering hepatic transcriptional networks.

2017-01-01 | GSE70477 | GEO

High-Fat High-Sugar Diet Induces Polycystic Ovary Syndrome in a Rodent Model

Project description:Obesity has been linked with a host of metabolic and reproductive disorders including polycystic ovary syndrome (PCOS). While a distinct link exists between obesity and PCOS, the exact pathogenesis of the disease remains less understood and limited research has explored the impact of diet on the development of PCOS. With the primary symptoms of PCOS including hyperandrogenism, anovulation, and polycystic ovaries, most animal models utilize androgen treatment to effectively induce PCOS. However, these models fail to address the underlying causes of disease symptoms and do not effectively demonstrate the metabolic features of the disease such as hyperinsulinemia. Here, we present a novel rodent model of diet-induced obesity that recapitulates both the metabolic and reproductive phenotypes of human PCOS. In utilizing a high-fat high-sugar (HFHS) diet, we have created a model of PCOS that allows for the study of metabolic parameters and their impact on ovarian follicle development and reproductive health. Animals on the HFHS diet not only demonstrated signs of metabolic impairment, but they also developed polycystic ovaries and experienced irregular estrous cycling marked by an extended period spent in estrus. Though hyperandrogenism was not characteristic of HFHS diet animals as a group, testosterone levels were predictive of a polycystic ovarian morphology. Importantly, PCOS was induced similarly to the disease etiology in humans, allowing this model to offer the unique opportunity to study PCOS at its genesis rather than following the development of disease symptoms.

2017-06-01 | GSE83220 | GEO

Temporal gene expression profiling of murine hippocampus with different diet regimens [Hippocampus]

Project description:In the present study, we used C57BL/6J mouse, as a model for studying diet-induced diabetes and obesity, since this strain accumulates adipose tissue mass, insulin resistance, hyper-insulinemia, and hyper-lipidemia similar to humans fed on an high-fat high-sugar diet (HFHSD).

2014-11-12 | GSE63174 | GEO

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [RNA-Seq]

Project description:To investigate the differentially expressed gene in head of adult flies which ancestors exposed in high sugar diet

2022-10-18 | GSE215756 | GEO

RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver]

Project description:RNA-seq was performed on samples of frozen tissue (liver, adipose, skeletal muscle, heart, and pancreatic islets) from the eight founder stains for the Diversity Outbred mice. The mice were fed a high-fat, high-sugar diet to sensitize them to the development of diabetes.

2024-05-13 | GSE266923 | GEO