Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: A.H. Smits
PROVIDER: PXD000172 | Pride | 2013-09-13
REPOSITORIES: Pride
van Nuland Rick R Smits Arne H AH Pallaki Paschalina P Jansen Pascal W T C PW Vermeulen Michiel M Timmers H T Marc HT
Molecular and cellular biology 20130318 10
Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) complexes that contain methyltransferase activity for H3K4 have been described, but a comprehensive and quantitative analysis of these SET1/MLL complexes is lacking. We applied label-free quantitative mass spectrometry to determine the subunit composition and stoichiometry of the human SET1/MLL complexes. We identifi ...[more]