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DNA repair in Mycoplasma gallisepticum

ABSTRACT: In the current study, we attempted to characterize the DNA repair system of Mycopalsma gallisepticum. We identified members of different DNA repair pathways based on genomic data and publications. We quantified mRNA of respective proteins per cell in a set of adverse conditions and identified most of them on the protein level. We showed induction of SOS-response in adverse conditions on a transcriptional level in the absence of a known regulator.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mycoplasma Gallisepticum

TISSUE(S): Cell Culture

SUBMITTER: Dmitry Alexeev

LAB HEAD: Dmitry Ischenko

PROVIDER: PXD000249 | Pride | 2014-07-30

REPOSITORIES: Pride

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DNA repair in Mycoplasma gallisepticum.

Gorbachev Alexey Y AY Fisunov Gleb Y GY Izraelson Mark M Evsyutina Darya V DV Mazin Pavel V PV Alexeev Dmitry G DG Pobeguts Olga V OV Gorshkova Tatyana N TN Kovalchuk Sergey I SI Kamashev Dmitry E DE Govorun Vadim M VM

BMC genomics 20131023

<h4>Background</h4>DNA repair is essential for the maintenance of genome stability in all living beings. Genome size as well as the repertoire and abundance of DNA repair components may vary among prokaryotic species. The bacteria of the Mollicutes class feature a small genome size, absence of a cell wall, and a parasitic lifestyle. A small number of genes make Mollicutes a good model for a "minimal cell" concept.<h4>Results</h4>In this work we studied the DNA repair system of Mycoplasma gallise ...[more]

PMID: 24148612

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