Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Dorothea Anrather
PROVIDER: PXD000405 | Pride | 2013-12-19
REPOSITORIES: Pride
Yelamanchi Syam Kumar SK Veis Jiri J Anrather Dorothea D Klug Helene H Ammerer Gustav G
Molecular and cellular biology 20131209 4
Downregulation of specific transcripts is one of the mechanisms utilized by eukaryotic checkpoint systems to prevent cell cycle progression. Here we identified and explored such a mechanism in the yeast Saccharomyces cerevisiae. It involves the Mec1-Rad53 kinase cascade, which attenuates G(2)/M-specific gene transcription upon genotoxic stress. This inhibition is achieved via multiple Rad53-dependent inhibitory phosphorylations on the transcriptional activator Ndd1 that prevent its chromatin rec ...[more]