Proteomics

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Melanoma NRAS - Cooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock

ABSTRACT: In the present work we propose a new therapy for NRAS mutant melanoma. Simultaneous inhibition of MEK and ROCK caused induction of BimEL , PARP, and Puma, and hence apoptosis. In vivo, MEK and ROCK inhibition suppressed growth of established tumors. Our findings warrant clinical investigation of the effectiveness of combinatorial targeting of MAPK/ERK and ROCK in NRAS mutant melanoma.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Whole Body

SUBMITTER: Teck Yew Low  

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD000528 | Pride | 2015-03-11

REPOSITORIES: Pride

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Dataset's files

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Action DRS
OR6_20130405_GM_NKI_NRAS_WP_Mix1_repl1_Fr12.raw Raw
OR6_20130405_GM_NKI_NRAS_WP_Mix1_repl1_Fr13.raw Raw
OR6_20130405_GM_NKI_NRAS_WP_Mix1_repl1_Fr14.raw Raw
OR6_20130405_GM_NKI_NRAS_WP_Mix1_repl1_Fr15.raw Raw
OR6_20130405_GM_NKI_NRAS_WP_Mix1_repl1_Fr16.raw Raw
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