HCMV-NEC analysis - Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human) Human Cytomegalovirus (strain Ad169) (hhv-5) (human Herpesvirus 5)
SUBMITTER: 
Yohann Couté
LAB HEAD: Christophe Bruley
PROVIDER: PXD000536 | Pride | 2014-06-30
REPOSITORIES: Pride
Publications
Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus.
Milbradt Jens J Kraut Alexandra A Hutterer Corina C Sonntag Eric E Schmeiser Cathrin C Ferro Myriam M Wagner Sabrina S Lenac Tihana T Claus Claudia C Pinkert Sandra S Hamilton Stuart T ST Rawlinson William D WD Sticht Heinrich H Couté Yohann Y Marschall Manfred M
Molecular & cellular proteomics : MCP 20140626 8
Herpesviral capsids are assembled in the host cell nucleus before being translocated into the cytoplasm for further maturation. The crossing of the nuclear envelope represents a major event that requires the formation of the nuclear egress complex (NEC). Previous studies demonstrated that human cytomegalovirus (HCMV) proteins pUL50 and pUL53, as well as their homologs in all members of Herpesviridae, interact with each other at the nuclear envelope and form the heterodimeric core of the NEC. In ...[more]
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