Proteomics

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Differentially expressed proteins in benign and malignant adrenocortical tumors

ABSTRACT: We have compared the microsomal protein fractions from benign and malignant adrenocortical tumors. Protein extracts were trypsinized, peptides separated by HiRIEF (high resolution isoelectric focusing) and analysed by LC-MS.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Hanna Kjellin  

PROVIDER: PXD000604 | Pride | 2014-02-11

REPOSITORIES: Pride

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Publications

Differentially expressed proteins in malignant and benign adrenocortical tumors.

Kjellin Hanna H   Johansson Henrik H   Höög Anders A   Lehtiö Janne J   Jakobsson Per-Johan PJ   Kjellman Magnus M  

PloS one 20140203 2

We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased levels in the malignant tissue compared to the benign. Additionally, several proteins belonging to complex I in the mitochondrial respiration chain showed decreased levels in the malignant tissue. Taken  ...[more]