Proteomics,Multiomics

Dataset Information

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Proteomics analysis of B. bigemina


ABSTRACT: Protein from B. bigemina PR cell lysates was analysed by 1D SDS PAGE and in solution digestion. Digested peptides were analysed by on-line nanoflow liquid chromatography using the nanoACQUITY-nLC system (Waters MS technologies, Manchester, UK) coupled to an LTQ-Orbitrap Velos (ThermoFisher Scientific, Bremen, Germany). Collected data were then analysed by Mascot (version 2.3.02, Matrix Science) and Progenesis LC–MS (version 4.1, Nonlinear Dynamics, UK).

OTHER RELATED OMICS DATASETS IN: PRJEB5046

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Babesia Sp. Babesia Bigemina

TISSUE(S): Blood Cell

SUBMITTER: Dong Xia  

PROVIDER: PXD000629 | Pride | 2014-06-16

REPOSITORIES: Pride

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Publications


Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic diversity in genes encoding VESA (ves1) through comparative analysis within and between three Babesia species, (B. bigemina, B. divergens and B. bovis). Ves1 structure diverges rapid  ...[more]

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