Ontology highlight
ABSTRACT:
INSTRUMENT(S): QSTAR
ORGANISM(S): Leishmania Donovani
SUBMITTER: Polina Tsigankov
LAB HEAD: Dan Zilberstein
PROVIDER: PXD000671 | Pride | 2014-04-24
REPOSITORIES: Pride
Tsigankov Polina P Gherardini Pier Federico PF Helmer-Citterich Manuela M Späth Gerald F GF Myler Peter J PJ Zilberstein Dan D
Molecular & cellular proteomics : MCP 20140416 7
Leishmania are obligatory intracellular parasitic protozoa that cause a wide range of diseases in humans, cycling between extracellular promastigotes in the mid-gut of sand flies and intracellular amastigotes in the phagolysosomes of mammalian macrophages. Although many of the molecular mechanisms of development inside macrophages remain a mystery, the development of a host-free system that simulates phagolysosome conditions (37 °C and pH 5.5) has provided new insights into these processes. The ...[more]