Name: Interactome of the Legionella pneumophila effector PieE
Keywords: Legionella pneumophila

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Interactome of the Legionella pneumophila effector PieE

ABSTRACT: The in vivo interactome of the Legionella pneumophila effector PieE reveals binding to multiple Rab GTPases

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Legionella Pneumophila

DISEASE(S): Legionellosis

SUBMITTER: James Wright

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD000706 | Pride | 2017-02-08

REPOSITORIES: Pride

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A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases.

Mousnier Aurélie A Schroeder Gunnar N GN Stoneham Charlotte A CA So Ernest C EC Garnett James A JA Yu Lu L Matthews Steve J SJ Choudhary Jyoti S JS Hartland Elizabeth L EL Frankel Gad G

mBio 20140812 4

<h4>Unlabelled</h4>Legionella pneumophila, the causative agent of Legionnaires' disease, uses the Dot/Icm type IV secretion system (T4SS) to translocate more than 300 effectors into host cells, where they subvert host cell signaling. The function and host cell targets of most effectors remain unknown. PieE is a 69-kDa Dot/Icm effector containing three coiled-coil (CC) regions and 2 transmembrane (TM) helices followed by a fourth CC region. Here, we report that PieE dimerized by an interaction be ...[more]

PMID: 25118235

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