Proteomics

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Discovery and Confirmation of a Protein Biomarker Panel with Potential to Predict Response to Biologic Therapy in Psoriatic Arthritis


ABSTRACT: An integrated discovery to targeted proteomics approach was used to investigate the protein profiles of good and non–responders to anti-TNF-alpha and T-cell inhibitor treatments in PsA patients. Reverse phase liquid chromatography coupled to tandem mass spectrometry was used to generate protein profiles of synovial tissue obtained at baseline from 10 PsA patients who then commenced anti-TNF-alpha therapy (adalimumab). Targeted proteomics using multiple reaction monitoring was used to confirm and pre-validate a potential protein biomarker panel in 18 and 7 PsA patient samples respectively.

INSTRUMENT(S): 6520 Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Synovial Tissue

DISEASE(S): Psoriatic Arthritis

SUBMITTER: Stephen Pennington  

LAB HEAD: Stephen Roy Pennington

PROVIDER: PXD000707 | Pride | 2019-12-17

REPOSITORIES: Pride

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Publications

Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis.

Ademowo Opeyemi S OS   Hernandez Belinda B   Collins Emily E   Rooney Cathy C   Fearon Ursula U   van Kuijk Arno W AW   Tak Paul-P PP   Gerlag Danielle M DM   FitzGerald Oliver O   Pennington Stephen R SR  

Annals of the rheumatic diseases 20140903 1


<h4>Objective</h4>Biological therapies, which include antitumour necrosis factor-α and T-cell inhibitors, are potentially effective treatments for psoriatic arthritis (PsA) but are costly and may induce a number of side effects. Response to treatment in PsA is variable and difficult to predict. Here, we sought to identify a panel of protein biomarkers that could be used to predict which patients diagnosed with PsA will respond to biologic treatment.<h4>Methods</h4>An integrated discovery to targ  ...[more]

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