Proteomics

Dataset Information

0

Synovial fluid proteome in rheumatoid arthritis


ABSTRACT: Rheumatoid arthritis (RA) is a chronic autoinflammatory disorder that affects small joints. Despite intense efforts, there isno definitive marker yet for early diagnosis RA and for monitoring the progression of this disease. We sought to catalog the proteins present in the synovial fluid of patients with rheumatoid arthritis. To identify lower abundance proteins, we undertook two approaches – we depleted the abundant proteins using a multiple affinity removal system (MARS14) column and we enriched glycoproteins using a lectin affinity column. The peptides were analyzed by LC-MS/MS on a high resolution Fourier transform mass spectrometer.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Rheumatoid Arthritis

SUBMITTER: Akhilesh Pandey  

LAB HEAD: Akhilesh Pandey

PROVIDER: PXD000740 | Pride | 2016-06-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
RA_SCX_CID-LTQ_1.raw Raw
RA_SCX_CID-LTQ_10.raw Raw
RA_SCX_CID-LTQ_11.raw Raw
RA_SCX_CID-LTQ_12.raw Raw
RA_SCX_CID-LTQ_13.raw Raw
Items per page:
1 - 5 of 79
altmetric image

Publications


<h4>Background</h4>Rheumatoid arthritis (RA) is a chronic autoinflammatory disorder that affects small joints. Despite intense efforts, there are currently no definitive markers for early diagnosis of RA and for monitoring the progression of this disease, though some of the markers like anti CCP antibodies and anti vimentin antibodies are promising. We sought to catalogue the proteins present in the synovial fluid of patients with RA. It was done with the aim of identifying newer biomarkers, if  ...[more]

Similar Datasets

2024-09-02 | BIOMD0000000550 | BioModels
2017-07-29 | GSE71841 | GEO
2022-06-23 | GSE176168 | GEO
2024-09-02 | BIOMD0000000549 | BioModels
2004-11-04 | GSE1919 | GEO
2023-05-18 | GSE216245 | GEO
2020-11-10 | GSE159117 | GEO
2023-01-09 | PXD035177 | Pride
2018-02-12 | GSE65908 | GEO
2023-01-09 | PXD035180 | Pride