Proteomic analysis of castrate resistant prostate cancer cell lines

ABSTRACT: In this study the development of androgen independence in a cell model of disease was selected as a mirror of to the events at play in the development of Castrate Resistant Prostate Cancer in-vivo. LNCaP cells which are androgen dependent and androgen independent sublines; LNCaP-Abl and LNCaP-Abl-Hof were subject to extensive fractionation by 1-D SDS PAGE and accurate mass-high resolution mass spectrometry (Q Exactive) to identify proteins whose expression was changes significantly in response to androgen independent growth.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Brian Morrissey  

LAB HEAD: Stephen Pennington

PROVIDER: PXD000751 | Pride | 2022-02-28

REPOSITORIES: Pride