Alterations in the membrane-associated proteome of alveolar macrophages in sarcoidosis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Macrophage
DISEASE(S): Pulmonary Sarcoidosis
SUBMITTER: 
Hanna Kjellin
LAB HEAD: Janne Lehtiö
PROVIDER: PXD000752 | Pride | 2016-12-23
REPOSITORIES: Pride
Publications
Alterations in the membrane-associated proteome fraction of alveolar macrophages in sarcoidosis.
Kjellin Hanna H Silva Ernesto E Branca Rui Mamede RM Eklund Anders A Jakobsson Per-Johan PJ Grunewald Johan J Lehtiö Janne J Wheelock Åsa M ÅM
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20160329 1
<h4>Background</h4>Alveolar macrophages are implicated in the pathogenesis of lung sarcoidosis. Their interaction with T-cells leads to an inflammatory response that may either resolve within 2 years, or become chronic with an increased risk to develop lung fibrosis.<h4>Objective</h4>To perform quantitative profiling of the membrane-associated proteome of alveolar macrophages in sarcoidosis patients and healthy individuals to identify specific proteins and pathways involved in sarcoidosis pathol ...[more]
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