Colon cancer stem cell over-expressing TAp63α

ABSTRACT: p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (N) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative proteomic analysis by stable isotope dimethyl labeling of colon cancer stem cells over-expressing TAp63α in order to investigate the cellular pathways modulated by this p63 isoform.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Simona D'Aguanno  

LAB HEAD: Prof. Andrea Urbani

PROVIDER: PXD000768 | Pride | 2014-03-17

REPOSITORIES: Pride