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Mitral Valve Tissue Shotgun Proteomics

ABSTRACT: In this study, we carried out a large-scale proteome profiling of human mitral valve tissues resected from patients with mitral valve prolapse.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Hwee Tong Tan

LAB HEAD: Hwee Tong Tan

PROVIDER: PXD000774 | Pride | 2015-05-07

REPOSITORIES: Pride

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Unravelling the proteome of degenerative human mitral valves.

Tan Hwee Tong HT Lim Teck Kwang TK Richards Arthur Mark AM Kofidis Theodoros T Teoh Kristine Leok-Kheng KL Ling Lieng H LH Chung Maxey C M MC

Proteomics 20150608 17

Degenerative mitral valve disease (DMVD), which includes the syndromes of mitral valve prolapse (MVP) and flail leaflet, is a common valvular condition which can be complicated by mitral regurgitation and adverse cardiovascular outcomes. Although several genetic and other studies of MVP in dog models have provided some information regarding the underlying disease mechanisms, the proteins and molecular events mediating human MVP pathogenesis have not been unraveled. In this study, we report the f ...[more]

PMID: 25914152

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