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Mitral Valve Tissue Shotgun Proteomics

ABSTRACT: In this study, we carried out a large-scale proteome profiling of human mitral valve tissues resected from patients with mitral valve prolapse.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Hwee Tong Tan

LAB HEAD: Hwee Tong Tan

PROVIDER: PXD000774 | Pride | 2015-05-07

REPOSITORIES: Pride

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			Action	DRS
	130626_HT__Spl_129_shotgun_10ul.group.xml	Xml
	130626_HT__Spl_129_shotgun_10ul.mzml	Mzml
	130626_HT__Spl_6035_shotgun_10ul.group.xml	Xml
	130626_HT__Spl_6035_shotgun_10ul.mzml	Mzml
	130626_HT__Spl_72_shotgun_10ul.group.xml	Xml

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Publications

Unravelling the proteome of degenerative human mitral valves.

Tan Hwee Tong HT Lim Teck Kwang TK Richards Arthur Mark AM Kofidis Theodoros T Teoh Kristine Leok-Kheng KL Ling Lieng H LH Chung Maxey C M MC

Proteomics 20150608 17

Degenerative mitral valve disease (DMVD), which includes the syndromes of mitral valve prolapse (MVP) and flail leaflet, is a common valvular condition which can be complicated by mitral regurgitation and adverse cardiovascular outcomes. Although several genetic and other studies of MVP in dog models have provided some information regarding the underlying disease mechanisms, the proteins and molecular events mediating human MVP pathogenesis have not been unraveled. In this study, we report the f ...[more]

PMID: 25914152

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Project description:We conducted single-cell RNA sequencing analysis of mitral valve leaflets extracted from six patients, comprising three individuals with moderate-to-severe functional mitral regurgitation and three nondiseased mitral valve controls. Bioinformatics was used to identify the cell types, describe the cell functions, and investigate cellular developmental trajectories and interactions.

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Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

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