Primary mouse embryonic palatal mesenchyme LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Cell, Early Embryonic Cell
SUBMITTER: 
Katherine Fantauzzo
LAB HEAD: Philippe Soriano
PROVIDER: PXD000779 | Pride | 2019-06-04
REPOSITORIES: Pride
Publications
PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways.
Fantauzzo Katherine A KA Soriano Philippe P
Genes & development 20140501 9
Previous studies have identified phosphatidylinositol 3-kinase (PI3K) as the main downstream effector of PDGFRα signaling during murine skeletal development. Autophosphorylation mutant knock-in embryos in which PDGFRα is unable to bind PI3K (Pdgfra(PI3K/PI3K)) exhibit skeletal defects affecting the palatal shelves, shoulder girdle, vertebrae, and sternum. To identify proteins phosphorylated by Akt downstream from PI3K-mediated PDGFRα signaling, we immunoprecipitated Akt phosphorylation substrate ...[more]
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