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Nucleus basalis of meynert proteome

ABSTRACT: In order to analyse the Nucleus Basalis of Meynert proteome in a large-scale format, we used a multi-dimensional fractionation approach which combines isolation of anatomically-defined nuclei, and protein/peptide chromatographic fractionation strategies coupled to mass spectrometry.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Disease Free

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD000805 | Pride | 2015-08-17

REPOSITORIES: Pride

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New insights into the human brain proteome: Protein expression profiling of deep brain stimulation target areas.

Fernández-Irigoyen Joaquín J Zelaya María Victoria MV Perez-Valderrama Estela E Santamaría Enrique E

Journal of proteomics 20150404 Pt B

Deep brain stimulation (DBS) is a neurosurgical procedure that provides therapeutic benefits for movement and affective disorders. The nucleus basalis of Meynert (NBM) and substantia nigra (SN) are considered target areas to apply DBS. Even though the degeneration of NBM and SN underlies the cognitive decline observed in neurological diseases, the protein knowledge derived from both areas is scarce. We have characterized the proteome present in both subcortical brain areas using the Triple TOF 5 ...[more]

PMID: 25845585

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