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Melanoma metastases: association between S100A13 expression and chemotherapy resistance

ABSTRACT: Here we have performed quantitative profiling of the proteome of lymph node metastasis from patients with melanoma with different response to chemotherapy.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Melanocyte, Lymph Node

DISEASE(S): Melanoma

SUBMITTER: Maria Pernemalm

LAB HEAD: Janne Lehtiö

PROVIDER: PXD000928 | Pride | 2014-04-25

REPOSITORIES: Pride

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Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.

Azimi A A Pernemalm M M Frostvik Stolt M M Hansson J J Lehtiö J J Egyházi Brage S S Hertzman Johansson C C

British journal of cancer 20140410 10

<h4>Background</h4>Disseminated cutaneous malignant melanoma (CMM) is commonly unresponsive to standard chemotherapies, and there are as yet no predictive markers of therapy response.<h4>Methods</h4>In the present study we collected fresh-frozen pretreatment lymph-node metastasis samples (n=14) from melanoma patients with differential response to dacarbazine (DTIC) or temozolomide (TMZ) chemotherapy, to identify proteins with an impact on treatment response. We performed quantitative protein pro ...[more]

PMID: 24722184

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