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The Haemophilus ducreyi LspA1 Protein Inhibits Phagocytosis By Using a New Mechanism Involving Activation of C-Terminal Src Kinase

ABSTRACT: LspA virulance factors of H. ducreyi inhibit phagocytosis by activating C-terminal Src kinase. This SILAC analysis identified Src kinase as the predominant mamallian protein interacting with the YL2 domain of LspA1.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: David Trudgian

LAB HEAD: Eric Hansen

PROVIDER: PXD000932 | Pride | 2014-04-29

REPOSITORIES: Pride

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The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.

Dodd Dana A DA Worth Randall G RG Rosen Michael K MK Grinstein Sergio S van Oers Nicolai S C NS Hansen Eric J EJ

mBio 20140520 3

<h4>Unlabelled</h4>Haemophilus ducreyi causes chancroid, a sexually transmitted infection. A primary means by which this pathogen causes disease involves eluding phagocytosis; however, the molecular basis for this escape mechanism has been poorly understood. Here, we report that the LspA virulence factors of H. ducreyi inhibit phagocytosis by stimulating the catalytic activity of C-terminal Src kinase (Csk), which itself inhibits Src family protein tyrosine kinases (SFKs) that promote phagocytos ...[more]

PMID: 24902122

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