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A normative study of the synovial fluid proteome from healthy porcine knee joints

ABSTRACT: Synovial fluid in an articulating joint contains proteins derived from blood transudates, and proteins that are produced by cells within joint tissues, such as synovium, cartilage, ligament, and meniscus. The proteome composition of healthy synovial fluid is not fully understood. Also not fully delineated are the cellular origins of synovial fluid components. We here present a normative proteomics study for synovial fluid optimized in pig.

INSTRUMENT(S): TripleTOF 5600, Q Exactive

ORGANISM(S): Homo Sapiens (human) Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Blood Plasma, Rheumatoid Arthritis Disease Specific Synovial Fluid, Synovia

DISEASE(S): Rheumatoid Arthritis

SUBMITTER: Tue Bjerg Bennike

LAB HEAD: Hanno Steen

PROVIDER: PXD000935 | Pride | 2014-09-09

REPOSITORIES: Pride

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A normative study of the synovial fluid proteome from healthy porcine knee joints.

Bennike Tue T Ayturk Ugur U Haslauer Carla M CM Froehlich John W JW Proffen Benedikt L BL Barnaby Omar O Birkelund Svend S Murray Martha M MM Warman Matthew L ML Stensballe Allan A Steen Hanno H

Journal of proteome research 20140903 10

Synovial fluid in an articulating joint contains proteins derived from the blood plasma and proteins that are produced by cells within the joint tissues, such as synovium, cartilage, ligament, and meniscus. The proteome composition of healthy synovial fluid and the cellular origins of many synovial fluid components are not fully understood. Here, we present a normative proteomics study using porcine synovial fluid. Using our optimized method, we identified 267 proteins with high confidence in he ...[more]

PMID: 25160569

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