Proteomics

Dataset Information

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Glioma stem cells - Membrane-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein/amino acid responses


ABSTRACT: Glioma stem cells treated with a drug (niguldipine) and the early response was monitored

INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Cell Culture

DISEASE(S): Glioblastoma

SUBMITTER: Gianluca Maddalo  

LAB HEAD: Albert J.R. Heck

PROVIDER: PXD000970 | Pride | 2017-02-02

REPOSITORIES: Pride

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Publications


Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining the efficacy of conventional chemotherapy. Here we report the discovery that inhibiting T-type voltage-gated Ca<sup>2+</sup> and K<sub>Ca</sub> channels can effectively induce selective cell death of GIC and increase host survival in an orthotopic mouse model of human glioma. At present, the precise cellular pathways affected by the drugs  ...[more]

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