Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Prostate Cancer Cell Line
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: Friedel Drepper
LAB HEAD: Bettina Warscheid
PROVIDER: PXD000985 | Pride | 2016-07-08
REPOSITORIES: Pride
Wiese Heike H Gelis Lian L Wiese Sebastian S Reichenbach Christa C Jovancevic Nikolina N Osterloh Markus M Meyer Helmut E HE Neuhaus Eva M EM Hatt Hanns H HH Radziwill Gerald G Warscheid Bettina B
Biochimica et biophysica acta 20140909 6
The prostate-specific G-protein-coupled receptor 1 (PSGR1) is an olfactory receptor specifically expressed in the prostate gland. PSGR1 expression is elevated both in benign prostatic hyperplasia tissue and in prostate cancer. Stimulation of PSGR1 by the odorant β-ionone leads to an increase in the intracellular Ca(2+) concentration, activation of mitogen-activated protein (MAP) kinases and a decrease in prostate cancer cell proliferation. To further extend our knowledge about PSGR1 signaling in ...[more]