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Proteomics analysis of cystic fluid from human cystic papillary thyroid carcinoma

ABSTRACT: Here we have performed quantitative and qualitative profiling of the proteome of cystic fluid from human cystic papillary thyroid carcinoma with the aim to identify specific proteins and pathways involved in cystic fluid from human cystic papillary carcinoma, as well as possible diagnostic markers.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Thyroid Nodule, Epithelial Cell Of Thyroid Gland

DISEASE(S): Papillary Thyroid Carcinoma

SUBMITTER: Maria Pernemalm

LAB HEAD: Janne Lehtiö

PROVIDER: PXD000996 | Pride | 2015-05-20

REPOSITORIES: Pride

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Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions.

Dinets Andrii A Pernemalm Maria M Kjellin Hanna H Sviatoha Vitalijs V Sofiadis Anastasios A Juhlin C Christofer CC Zedenius Jan J Larsson Catharina C Lehtiö Janne J Höög Anders A

PloS one 20150515 5

Cystic papillary thyroid carcinoma (cPTC) is a subgroup of PTC presenting a diagnostic challenge at fine needle aspiration biopsy (FNAB). To further investigate this entity we aimed to characterize protein profiles of cyst fluids from cPTC and benign thyroid cystic lesions. In total, 20 cPTCs and 56 benign thyroid cystic lesions were studied. Profiling by liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed on cyst fluids from a subset of cases after depletion, and selected pr ...[more]

PMID: 25978681

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