Dataset Information

Gastric cancer_iTRAQ - Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells

ABSTRACT: Using quantitative proteomics-isobaric tags for relative and absolute quantification (iTRAQ), we characterize the mechanism of TIIA regulation in gastric cancer cell line AGS.

INSTRUMENT(S): Synapt G2 HDMS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Stomach Carcinoma

SUBMITTER: Li-Ling Lin

LAB HEAD: Hsueh-Fen Juan

PROVIDER: PXD000998 | Pride | 2016-07-08

REPOSITORIES: Pride

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Publications

Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells.

Lin Li-Ling LL Hsia Chieh-Ren CR Hsu Chia-Lang CL Huang Hsuan-Cheng HC Juan Hsueh-Fen HF

BMC genomics 20150205

<h4>Background</h4>Tanshinone IIA (TIIA) is a diterpene quinone extracted from the plant Danshen (Salvia miltiorrhiza) used in traditional Chinese herbal medicine. It has been reported to have anti-tumor potential against several kinds of cancer, including gastric cancer. In most solid tumors, a metabolic switch to glucose is a hallmark of cancer cells, which do this to provide nutrients for cell proliferation. However, the mechanism associated with glucose metabolism by which TIIA acts on gastr ...[more]

PMID: 25652794

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Dataset Information

Gastric cancer_iTRAQ - Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells

Publications

Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells.

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