Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Hela Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Ivo Hendriks
LAB HEAD: Alfred C.O. Vertegaal
PROVIDER: PXD001061 | Pride | 2014-09-04
REPOSITORIES: Pride
Hendriks Ivo A IA D'Souza Rochelle C J RC Yang Bing B Verlaan-de Vries Matty M Mann Matthias M Vertegaal Alfred C O AC
Nature structural & molecular biology 20140914 10
SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution MS, we have studied global SUMOylation in human cells in a site-specific manner, identifying a total of >4,300 SUMOylation sites in >1,600 proteins. To our knowledge, this is the first time that >1,000 SUMOylation sites have been identified under standard growth conditions. We quantitatively studied SUMOylation dynamics in response to SUMO protease inhibition, proteasome inhibition a ...[more]